BOC-D-GLUTAMIC ACID-OTBU

BOC-D-GLUTAMIC ACID-OTBU - Names and Identifiers

Name	Boc-D-Glu-OtBu
Synonyms	BOC-D-GLU-OTBU Boc-D-Glu-OtBu BOC-D-GLUTAMIC ACID-OTBU Boc-D-glutamicacid1-tert-butylester Boc-D-glutamic acid 1-tert-butyl ester BOC-D-GLUTAMIC ACID ALPHA-T-BUTYL ESTER N-Boc-D-glutamic acid 1-(tert-butyl) ester N-ALPHA-T-BUTOXYCARBONYL-D-GLUTAMIC ACID ALPHA-T-BUTYL ESTER N-[(1,1-Dimethylethoxy)carbonyl]-D-glutamic acid 1-(tert-butyl) ester (4R)-5-[(2-Methyl-2-propanyl)oxy]-4-({[(2-Methyl-2-propanyl)oxy]carbonyl}aMino)-5-oxopentanoic acid (non-preferred naMe)
CAS	73872-71-6

BOC-D-GLUTAMIC ACID-OTBU - Physico-chemical Properties

Molecular Formula	C14H25NO6
Molar Mass	303.35
Density	1.121
Boling Point	449.8±40.0 °C(Predicted)
Appearance	Powder
Color	White to pale brown
pKa	4.48±0.10(Predicted)
Storage Condition	Sealed in dry,2-8°C

BOC-D-GLUTAMIC ACID-OTBU - Introduction

N-tert-Butoxycarbonyl-D-glutamic acid 1-tert-butyl ester (Boc-D-Glu-OtBu) is an organic compound. The following is a description of its nature, use, preparation and safety information:

Nature:
N-tert-Butoxycarbonyl-D-glutamic acid 1-tert-butyl ester is a solid and odorless at room temperature. It has low solubility and is soluble in organic solvents such as dimethylformamide (DMF) or dichloromethane.

Use:
N-tert-Butoxycarbonyl-D-glutamic acid 1-tert-butyl ester is commonly used as a protecting group in organic synthesis. The carboxyl group on the D-glutamic acid residue of this compound is condensed with a tert-butoxycarbonyl group (Boc group) to protect its reactivity. Boc-D-Glu-OtBu can be used as precursor molecules of synthetic peptides or proteins, which are used to synthesize polypeptides and proteins in drug or biological research.

Preparation Method:
The preparation of Boc-D-Glu-OtBu is usually obtained by reacting 1-tert-butanol having a D-glutamic acid residue with N-tert-butoxycarbonyl-N'-carbonyldi-tert-butylurea (Boc-NH-Dpnp). The reaction is generally carried out in an organic solvent and is catalyzed by the addition of a base.

Safety Information:
N-tert-Butoxycarbonyl-D-glutamic acid 1-tert-butyl ester is a chemical that should be handled and stored properly. When in use, wear appropriate personal protective equipment such as laboratory gloves and safety glasses. Avoid contact with skin and eyes. If exposed or inhaled, flush with water and seek medical advice. When stored, it should be kept in a cool, dry place, and away from fire and oxidizing agents. Detailed safety information can be found in the safety data sheets of the relevant chemical materials.

Last Update：2024-04-09 15:17:59